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Dealing with private property for public purposes
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Samenvatting Hoofdstuk 1 * In dit proefschrift worden de resultaten beschreven van een onderzoek naar grondtransacties tussen de overheid en private grondeigenaren. Grondtransacties hebben vaak een belangrijke invloed op de bestemming van grond en zijn daarmee nauw gerelateerd aan ruimtelijke planning. Een perceel grond is niet te verplaatsen en elk stuk grond is uniek vanwege de ruimtelijke locatie. Dit zorgt ervoor dat elke grondeigenaar een monopolypositie heeft. Voor overheden kan het belang van grond(eigendom) groot zijn als geplande ontwikkelingen niet worden gerealiseerd door de betreffende grondeigenaren zelf. Er zijn verschillende studies gedaan naar de relatie tussen grondbeleid, grondverwerving en de grondmarkt. Het onderzoek dat..

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Developing a Service Platform for Health and Wellbeing in a Living Lab Setting
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Since 2015 the Dutch national government emphasizes the shift from a welfare society towards a participatory society. In the long term, this shift could have a huge effect on society and the social inclusiveness of elderly people. Mainly because participatory societies build on peoples own responsibilities for their health and wellbeing and making people help each other, which requires a different mindset on the part of citizens. New legislations in the Netherlands means new ways for municipalities to collaborate, but at the same time it is important to: 1) balance financial costs and benefits, 2) spread risks, 3) ensure service quality, and 4) manage and safeguard the social system...

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Development and application of glyco-bioinformatics packages for targeted quantitation
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This thesis describes the development of novel methods for the targeted quantitation of glycomics and glycoproteomics data. The developed methods proved to be at least on par and in several cases superior to commercially available methods in terms of accuracy of the results. The developed methods also provided several new parameters that could be used for the curation of both the analytes and the measurements, increasing the quality of the final data. Lastly, the developed methods were applied on several cohorts revolving around pregnancy and childbirth. For example, the differences in the total plasma N-glycosylation throughout a pregnancy and after the delivery were investigated by using the developed methods...

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Diagnostics In Celiac Disease
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Celiac disease (CD) is characterized by an inadequate immune response to gluten, a storage protein in wheat and the related grain species barley and rye. This immune reaction, giving intestinal inflammation and malabsorption, will only occur in genetically susceptible individuals carrying specific human leukocyte antigen (HLA) heterodimers, and consists primarily of a gluten specific T-cell response, although a specific antibody response is also present...

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Diet, postprandial metabolism and endothelial function: effects of lutein-enriched eggs and trans-resveratrol
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The metabolic syndrome (MetS) includes a set of abnormalities in metabolic risk markers that increases the risk for developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). For many years, several definitions for the MetS made by different societies, existed side-by-side...

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Dietary intake and body-growth in cystic fibrosis
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Cystic fibrosis (CF) is a life-threatening genetic disorder that affects mostly the lungs but also the pancreas, liver and intestine. CF is characterised by chronic pulmonary inflammation resulting in a gradual, progressive decline in pulmonary function. The vast majority of CF patients also have an exocrine pancreatic insufficiency, resulting in inadequate digestion and leading to fat malabsorption and malnutrition...

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