Jeroen Tielbeek
MRI for grading Crohn's disease

Inflammatory bowel diseases are a large healthcare problem in the western world; they affect over two million citizens in Europe alone. The diseases result from inappropriate inflammatory responses to intestinal microbes in a genetically susceptible host. They comprise of two types of chronic intestinal disorders: Crohn's disease and ulcerative colitis...

Open eBook
Agon Hyseni
Nanobody Technology In Thrombosis And Haemostasis Research

The endothelium is one of the largest organs in the human body with an estimated total area of blood-endothelium interface of 350m². It envelops the flowing blood in a continuous layer of cells and performs a myriad of functions in fluid exchange, blood pressure control, inflammatory responses and coagulation regulation. Under physiological conditions, the endothelial surface is a potent anticoagulant that inhibits platelet adhesion and blood clotting...

Open eBook
Martijn Vink
Navigating Frames, A study of the interplay between meaning and power in policy deliberations over adaptation to climate change

When in the age of discovery European sailors set sail for new sea routes and unknown destinations, the perception of the world employed in navigating it was often far from how we understand the world today. Still, navigating was not unsuccessful: centuries of European consensus on the flat nature of the earth did not hinder sailors from roaming -the upper- half of it...

Open eBook
Annegreet Veldhuis-Vlug
Neuroendocrine Regulation of Human Bone Metabolism

In the first part of this thesis we investigated the role of the sympathetic nervous system in human bone metabolism and hematopoiesis and in the second part we investigated the hormonal control of bone and bone marrow. Chapter 1 presents an introduction to human bone metabolism, bone marrow physiology and the sympathetic nervous system...

Open eBook
Fawzy Farag
New Diagnostic Techniques For Functional Lower Urinary Tract Disorders

Lower Urinary Tract Symptoms (LUTS) are divided into storage phase symptoms, voiding phase symptoms and post micturition symptoms. Overactive bladder (OAB) syndrome is one of the storage phase disorders that presents with urgency with or without urgency incontinence, usually with frequency and nocturia in absence of infection or any other obvious pathology...

Open eBook
Tim Peters
Non-coding RNA species in heart failure

The aim of this thesis was to extend our knowledge on the role of different non-coding RNA species in the development of heart failure (HF). Over the last years it has been acknowledged that multiple cell types are critically involved in HF, including cardiomyocytes, cardiac fibroblasts, and resident or infiltrating immune cells. This thesis comprises research on the involvement of these three cell types in HF with a focus on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as regulators of cell function. Only very recently, the cell type-specific effects of miRNAs in HF and their role in paracrine signaling have come to the center of attention1-5. Here we extend this knowledge by identifying miR-139 as regulator of cardiomyocyte funct..

Open eBook
Lodewijk Vijftigschild
Novel diagnostic and therapeutic opportunities for Cystic Fibrosis

Curative treatments for CF patients are still an unmet need. In this thesis, we developed new approaches that can assist the identification and development of CFTR-targeting treatments, and to use those treatments in a more personalized fashion. These included an improved fluorescent sensor for CFTR function measurement in heterologous expression systems. We also applied a primary cell model to study drugs that modulate CFTR function. This primary cell model allowed us to perform small scale screening for existing biological and chemical modulators of CFTR, which may upon pharmacological targeting be useful for treatment of CF. Our data provided important insights into individual mechanisms that may impact the efficacy of such drugs in vivo..

Open eBook
Jonas Kuiper
Novel insights into the pathogenesis of Birdshot chorioretinopathy

Birdshot chorioretinopathy (BSCR) is an organ-specific, presumably autoimmune disorder of the eye affecting most often middle-aged and elderly individuals of European descent. BSCR manifests as a severe, progressive intraocular inflammation of the posterior eye segment, typically leading to extensive retinal atrophy, visual loss and is potentially blinding...

Open eBook
Marlous Hoogstraat
On the heterogeneity of tumor sequencing

There is one statement you cannot avoid in cancer research: “Cancer is a disease of the genome”. More than a century ago, even before the discovery of DNA, researchers observed that cancer cells show aberrant chromosomes and cell division1. It was discovered later that these aberrant chromosomes and other, smaller damages to the DNA are actually causing the cells to become cancerous, not just being the result thereof...

Open eBook
Showing 121 to 135 of 226 (16 Pages)