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Martijn Vink
Navigating Frames, A study of the interplay between meaning and power in policy deliberations over adaptation to climate change
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When in the age of discovery European sailors set sail for new sea routes and unknown destinations, the perception of the world employed in navigating it was often far from how we understand the world today. Still, navigating was not unsuccessful: centuries of European consensus on the flat nature of the earth did not hinder sailors from roaming -the upper- half of it...

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Annegreet Veldhuis-Vlug
Neuroendocrine Regulation of Human Bone Metabolism
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In the first part of this thesis we investigated the role of the sympathetic nervous system in human bone metabolism and hematopoiesis and in the second part we investigated the hormonal control of bone and bone marrow. Chapter 1 presents an introduction to human bone metabolism, bone marrow physiology and the sympathetic nervous system...

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Fawzy Farag
New Diagnostic Techniques For Functional Lower Urinary Tract Disorders
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Lower Urinary Tract Symptoms (LUTS) are divided into storage phase symptoms, voiding phase symptoms and post micturition symptoms. Overactive bladder (OAB) syndrome is one of the storage phase disorders that presents with urgency with or without urgency incontinence, usually with frequency and nocturia in absence of infection or any other obvious pathology...

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Tim Peters
Non-coding RNA species in heart failure
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The aim of this thesis was to extend our knowledge on the role of different non-coding RNA species in the development of heart failure (HF). Over the last years it has been acknowledged that multiple cell types are critically involved in HF, including cardiomyocytes, cardiac fibroblasts, and resident or infiltrating immune cells. This thesis comprises research on the involvement of these three cell types in HF with a focus on microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) as regulators of cell function. Only very recently, the cell type-specific effects of miRNAs in HF and their role in paracrine signaling have come to the center of attention1-5. Here we extend this knowledge by identifying miR-139 as regulator of cardiomyocyte funct..

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Lodewijk Vijftigschild
Novel diagnostic and therapeutic opportunities for Cystic Fibrosis
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Curative treatments for CF patients are still an unmet need. In this thesis, we developed new approaches that can assist the identification and development of CFTR-targeting treatments, and to use those treatments in a more personalized fashion. These included an improved fluorescent sensor for CFTR function measurement in heterologous expression systems. We also applied a primary cell model to study drugs that modulate CFTR function. This primary cell model allowed us to perform small scale screening for existing biological and chemical modulators of CFTR, which may upon pharmacological targeting be useful for treatment of CF. Our data provided important insights into individual mechanisms that may impact the efficacy of such drugs in vivo..

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Jonas Kuiper
Novel insights into the pathogenesis of Birdshot chorioretinopathy
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Birdshot chorioretinopathy (BSCR) is an organ-specific, presumably autoimmune disorder of the eye affecting most often middle-aged and elderly individuals of European descent. BSCR manifests as a severe, progressive intraocular inflammation of the posterior eye segment, typically leading to extensive retinal atrophy, visual loss and is potentially blinding...

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Marcel Boonen
Nurses in Space
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Marlous Hoogstraat
On the heterogeneity of tumor sequencing
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There is one statement you cannot avoid in cancer research: “Cancer is a disease of the genome”. More than a century ago, even before the discovery of DNA, researchers observed that cancer cells show aberrant chromosomes and cell division1. It was discovered later that these aberrant chromosomes and other, smaller damages to the DNA are actually causing the cells to become cancerous, not just being the result thereof...

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Johanne Sondergaard
Opinionated Family Migration Policies?
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Opinionated Family Migration Policies? Public opinion and resistance to EU harmonization of family reunification policies in Europe. Despite the harmonizing efforts of the European Union [EU], family reunification policies remain diverse across its member states in terms of, among many other aspects, income requirements for sponsors and the requirements for the reuniting family member obtaining an autonomous residence permit. This thesis examines whether member states’ resistance to the harmonization of family migration policies can be partly explained by divergent public opinion about gender roles and/or about immigration/immigrants across the EU. Using data from the European Social Survey (2002-2012), the European Value Study (1990-2008) ..

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Yvette Baggen
Opportunity Identification Competence
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Opportunity identification by employees Opportunities and their identification are of significant importance for competitiveness in today’s complex and turbulent business environment because they serve as a key influencing factor for new value-creation. Opportunity identification (OI) is interesting not only from the perspective of new business start-ups, but also from the perspective of employees in existing organisations. Each entrepreneurial process starts with an imagined, rudimentary idea in the mind of an individual. The further exploration and development of such opportunities by employees can lead to the realisation of all kinds of corporate entrepreneurship outcomes, such as innovation, strategic renewal, and internal or external ..

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Aram van Brussel
Optical Molecular Imaging Of Hypocix Breast Cancer
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In The Netherlands, approximately one third of women is diagnosed with cancer during their life span of which breast cancer is the most common form. Of all breast cancer patients, one third will eventually die of metastatic disease...

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