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Sylvia Huwae
Different cultures, different selves?
ebook000141

This dissertation examined the usefulness of the IC-framework by examining how people across cultures regulate their emotions during social interactions and respond to transgressions in various settings with various people. For this, we used a combination of methods. Our samples included participants with Dutch, Chinese and Moluccan backgrounds. Our studies showed that, even though participants from individualistic and collectivistic cultures differed in how they suppressed emotions and responded to transgressions, their responses also depended upon the situations that they were in and on how close they were with those who were present. As such, our findings present a nuanced view on characterizing cultures as either individualistic or coll..

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Michelle Jansen
Shaping of Adaptive Immunity and Celiac Disease Autoimmunity in a Population based Childhood Cohort
ebook000139

De studies beschreven in deel 1 van dit proefschrift illustreren de complexe en grote leeftijdsafhankelijke interindividuele variabiliteit van het adaptieve immuunsysteem op de kinderleeftijd. Herpesvirus infecties zijn een van de meest belangrijke omgevingsdeterminanten die het immuunsysteem vormgeven. De studies in deel II beschrijven determinanten en consequenties van coeliakie auto-immuniteit in een gezonde populatie kinderen. Coeliakie auto-immuniteit op de kinderleeftijd is geassocieerd met verminderde gewichtstoename en verminderde botdichtheid, welke de noodzaak voor het verbeteren van vroege diagnose en behandeling benadrukken. Daarnaast blijkt dat screening op  tissue-transglutaminase type 2 antistoffen (TG2A) in de algemene popul..

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Robert Mans
Strategies and genetic tools for engineering free-energy conservation in yeast
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Microorganisms can be used as ‘cell factories’ to convert sugars into valuable products, in some cases providing a more sustainable alternative to petrochemical productions. These microbial fermentations preferably occur in the absence of oxygen, as aeration of large-scale bioreactors is expensive and part of the sugars is respired to CO2, thereby lowering the product yield. To enable anaerobic product formation, the metabolic pathway from sugar to product has to provide some energy (usually in the form of ATP) which the microorganisms use to grow and maintain themselves. To enable the anaerobic production of a wider range of valuable chemicals with microorganisms, the conservation of free-energy (ATP) in the metabolic reactions can be opti..

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Nadine van Westrhenen
The art of healing: Traumatic stress and creative therapy in South Africa
ebook000131

Zuid-Afrika heeft een van de hoogste trauma en misbruikcijfers ter wereld, veel kinderen groeien op in extreme armoede en gewelddadige leefgemeenschappen. Veel kinderen ontwikkelen zogenoemde posttraumatische stress symptomen; dit zijn klachten zoals nachtmerries, slaapproblemen, prikkelbaar zijn, concentratieproblemen en herbelevingen. In onze studie bleek dat ruim 50% van de ondervraagden na blootstelling van een schokkende gebeurtenis hier last van had; dit is ontzettend hoog. Bovendien is de geestelijke gezondheidszorg die deze kinderen van hun klachten af kan helpen slecht toegankelijk voor kinderen die opgroeien in kansarme wijken, waar juist veel hulp nodig is. Wij hebben daarom een creatief therapie programma ontwikkeld, waarbij act..

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Bas Jansen
Development and application of glyco-bioinformatics packages for targeted quantitation
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This thesis describes the development of novel methods for the targeted quantitation of glycomics and glycoproteomics data. The developed methods proved to be at least on par and in several cases superior to commercially available methods in terms of accuracy of the results. The developed methods also provided several new parameters that could be used for the curation of both the analytes and the measurements, increasing the quality of the final data. Lastly, the developed methods were applied on several cohorts revolving around pregnancy and childbirth. For example, the differences in the total plasma N-glycosylation throughout a pregnancy and after the delivery were investigated by using the developed methods...

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