Wally Keijzer-Broers
Developing a Service Platform for Health and Wellbeing in a Living Lab Setting

Since 2015 the Dutch national government emphasizes the shift from a welfare society towards a participatory society. In the long term, this shift could have a huge effect on society and the social inclusiveness of elderly people. Mainly because participatory societies build on peoples own responsibilities for their health and wellbeing and making people help each other, which requires a different mindset on the part of citizens. New legislations in the Netherlands means new ways for municipalities to collaborate, but at the same time it is important to: 1) balance financial costs and benefits, 2) spread risks, 3) ensure service quality, and 4) manage and safeguard the social system...

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Bas Jansen
Development and application of glyco-bioinformatics packages for targeted quantitation

This thesis describes the development of novel methods for the targeted quantitation of glycomics and glycoproteomics data. The developed methods proved to be at least on par and in several cases superior to commercially available methods in terms of accuracy of the results. The developed methods also provided several new parameters that could be used for the curation of both the analytes and the measurements, increasing the quality of the final data. Lastly, the developed methods were applied on several cohorts revolving around pregnancy and childbirth. For example, the differences in the total plasma N-glycosylation throughout a pregnancy and after the delivery were investigated by using the developed methods...

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Amani Mubarak
Diagnostics In Celiac Disease

Celiac disease (CD) is characterized by an inadequate immune response to gluten, a storage protein in wheat and the related grain species barley and rye. This immune reaction, giving intestinal inflammation and malabsorption, will only occur in genetically susceptible individuals carrying specific human leukocyte antigen (HLA) heterodimers, and consists primarily of a gluten specific T-cell response, although a specific antibody response is also present...

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Sanne van der Made
Diet, postprandial metabolism and endothelial function: effects of lutein-enriched eggs and trans-resveratrol

The metabolic syndrome (MetS) includes a set of abnormalities in metabolic risk markers that increases the risk for developing cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). For many years, several definitions for the MetS made by different societies, existed side-by-side...

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Willie Woestenenk
Dietary intake and body-growth in cystic fibrosis

Cystic fibrosis (CF) is a life-threatening genetic disorder that affects mostly the lungs but also the pancreas, liver and intestine. CF is characterised by chronic pulmonary inflammation resulting in a gradual, progressive decline in pulmonary function. The vast majority of CF patients also have an exocrine pancreatic insufficiency, resulting in inadequate digestion and leading to fat malabsorption and malnutrition...

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Karianna Teunissen
Dietary proteins and blood pressure regulation

Cardiovascular diseases (CVD) are responsible for 30% of all deaths world wide. In the Netherlands, CVD were the second major cause of mortality, accounting for 28% of deaths in 2012. One of the risk factors for CVD is hypertension. Over 25% of adults world-wide was estimated to have hypertension in the year 2000...

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Jacqueline Tol
Dietetics and weight management in primary health care

Noncommunicable diseases (NCDs), such as cardiovascular diseases, cancers, chronic respiratory diseases and diabetes are increasing around the world and are the biggest cause of death globally. Unhealthy lifestyles, including unhealthy dietary patterns, are among the key risk factors for these NCDs...

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Sylvia Huwae
Different cultures, different selves?

This dissertation examined the usefulness of the IC-framework by examining how people across cultures regulate their emotions during social interactions and respond to transgressions in various settings with various people. For this, we used a combination of methods. Our samples included participants with Dutch, Chinese and Moluccan backgrounds. Our studies showed that, even though participants from individualistic and collectivistic cultures differed in how they suppressed emotions and responded to transgressions, their responses also depended upon the situations that they were in and on how close they were with those who were present. As such, our findings present a nuanced view on characterizing cultures as either individualistic or coll..

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Marieke Battjes-Fries
Effectiveness of nutrition education in Dutch primary schools

Healthy eating behaviour in childhood is important for children’s growth and development and might protect against the development of obesity and chronic diseases later in life. The school environment provides an effective setting for teaching children about nutrition and healthy eating behaviour. Therefore, school-based nutrition education programmes have increasingly been used in the past few decades to teach children about nutrition and to provide them with the skills to make healthy food choices. However, evaluating these programmes is complex, and studies have shown varying effects. As the programmes differ in content and delivery, it is hard to identify what intervention components and implementation conditions are most effective. Fur..

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Elmar Tobi
Epigenetic differences after prenatal adversity: The Dutch Hunger Winter

The central dogma of biology states that heritable information is passed residue-by-residue from DNA to RNA and finally protein. Moreover it states that such information cannot be transferred back to protein or nucleic acid...

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