Anirudh Prahallad
Identifying rational combination therapies for colorectal cancer using functional genetics

Cancer treatment over the past decade has increasingly been directed towards targeting specific molecular pathways involved in tumour cell proliferation and survival. Compared with the relatively non-selective cytotoxic chemotherapies, targeting specific molecular pathways provides an opportunity to achieve a high degree of cancer selectivity through biochemical specificity...

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Stefan Bouwense
Systematic mechanism-orientated approach to chronic pancreatitis pain

Chronic pancreatitis is a disease involving progressive inflammatory changes in the pancreas, usually leading to impairment of endocrine and exocrine function. Taking the data for European countries together, the incidence is approximately 6.0 per 100.000 inhabitants...

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Liesbeth Schrijvers
Exploring self-management and adherence in haemophilia

Haemophilia is an X-linked recessive disease. Lack or absence of clotting Factor VIII (haemophilia A) or IX (haemophilia B) results in excessive bleeding. The severity of the disease is determined by the percentage of clotting factor VIII or IX present in the blood. Patients with mild haemophilia (>5%) are rarely affected by bleeds, only in case of trauma or surgery. Patients with moderate haemophilia (1-5%) have a great variety in symptoms, ranging from no bleeds at all to spontaneous bleeds...

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Guus Heynen
Using functional genetics to identify components of cancer relevant signaling pathways

Signaling pathways have pivotal roles in the cell's physiology. They relay information from the cell's outside to the cell's interior and vice versa. This way cells can dynamically react to changing conditions in the extracellular milieu, communicate with other cells and make cell fate decisions like proliferation, cell growth, differentiation, apoptosis and migration...

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Jan Dieleman
Corticosteroids for cardiac surgery: a continuing controversy

Open heart surgery is among the most commonly performed surgical procedures. For most patients these expensive, high volume procedures lead to significant improvements in symptoms of acquired cardiac disease and quality of life. However, despite important improvements in surgical techniques, anaesthesia management, and postoperative care, cardiac surgery is still associated with a substantial risk of major adverse events, including mortality, stroke, myocardial infarction and postoperative organ failure...

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Stijn Heijmink
MR Imaging of Prostate Cancer at 3T: the Pros and Cons of Scanning with Endorectal Coil

In the diagnostic process of prostate cancer, several radiologic imaging modalities significantly contribute to the detection and localization of the disease. These range from transrectal ultrasound (TRUS) and magnetic resonance imaging (MRI) to positron emission tomography (PET)...

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Stjepan Picek
Applications of Evolutionary Computation to Cryptology

The world has become a global village. This statement represents more than just a phrase. When Karinthy published his “Six degrees of separation” theory more than 80 years ago, it sounded almost unbelievable. Despite the fact that the human population grew several times larger in the meantime, that theory sounds more true today than ever before (although, strictly speaking it is not true if we consider isolated Amazonian tribes, for example)...

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John Coppens
Kwaliteit en kwaliteitsmanagement in de gemeentelijke organisatie

Werken aan kwaliteitsverbeteringen door Nederlandse overheidsorganisaties is een actueel thema. Dat blijkt uit de doelstelling van de staatssecretaris van het Ministerie van Binnenlandse Zaken en Koninkrijksrelaties (BZK), om bij de dienstverlening van de overheid de vraag van de burger1 centraal te stellen...

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Marco Goeijenbier
Haemostasis and Virus infections

Viral infections of any kind can influence the haemostatic balance. This means that during, or shortly after infection with certain viruses the ability of blood to clot in humans can be drastically changed which can lead to both thrombotic as well as haemorrhagic complications. Direct or indirect activation of the endothelium by viruses (or other pathogens) may result in alterations in the coagulation- and the fibrinolytic systems...

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Anja Visser
Spirituality and adjustment to cancer

In this dissertation I investigate the question: What is the role of spirituality in the psychological adjustment to cancer? The diagnosis and treatment of cancer bring about many challenges. For one, the association of cancer with death can bring into awareness that there are boundaries to a person's existence. This can raise existential questions about why this is happening to the person and what he/she finds important in life...

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Robert van der Burgh
Mechanisms that Kindle Disease in Periodic Hereditary Diseases

The human body is equipped with an intricate system to protect itself from pathogens and foreign material. The innate defense provides the first line of protection. The detection of foreign material triggers two immediate reactions. First, it causes an enzymatic reaction called the complement cascade that opsonizes the material and stimulates its phagocytosis...

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Peter Ruijten
Responses to Human-like Artificial Agents

Technology has become a major part of our daily lives, as it has entered almost every arena of human society. Computers operate everywhere from people's homes and the streets to their workplaces. They come in so many shapes and sizes that it is sometimes difficult to recognize them...

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Siamaque Kazem
The Trichodysplasia SpinulosaAssociated Polyomavirus

Until a few years ago, the polyomavirus family (Polyomaviridae) included only a dozen viruses mostly identified in avian and mammalian hosts. Two of these, the JC and BK-polyomaviruses  isolated a long time ago, are known to infect humans and cause severe illness in immunocompromised hosts...

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Joost Raaphorst
Cognition and Behavior in Motor Neuron Disease

Progressive muscular atrophy (PMA) and amyotrophic lateral sclerosis (ALS) are collectively known as motor neuron disease (MND). Depending on the clinical involvement of the lower or upper motor neuron (LMN, UMN) a diagnosis of PMA (LMN only) or ALS (LMN and UMN) will be reached.1 Ninety percent of MND patients are sporadic cases and 10% are familial, often with an autosomal dominant inheritance...

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Natasha Appelman-Dijkstra
Long-term consequences of Growth Hormone replacement and cranial radiation on pituitary function

The pituitary is a small gland that lies within the sella turcica, a recess in the sphenoid bone. Despite its small size, the pituitary gland is an important regulator of hormone homeostasis. Under the control of hypothalamic peptides, the anterior lobe, or adenohypophysis, synthesizes and secretes growth hormone (GH), prolactin, adreno-corticotroph hormone (ACTH), thyroid stimulating hormone (TSH), and the gonadotrophs LH and FSH...

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