Paddy Janssen
Time Will Tell-Genetic influences on ejaculation time

The history of premature ejaculation (PE) is a history of contrasting hypotheses and sometimes vehement debates among medical specialists and psychologists, but it is also the history of pioneering clinicians and neuroscientists, who all together and throughout the years contributed to a better insight in a syndrome that for a very long time has been neglected in medical sexology and general medicine (Waldinger 2013)...

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Thom Stams
Torsade de Pointes

A central aim in this thesis is the risk prediction of Torsade de Pointes (TdP) arrhythmias. But the ultimate goal is to evaluate the role of altered ventricular activation, especially whether a chronic dyssynchronous ventricular activation pattern can have a proarrhythmic effect...

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Tamarinde Laura Haven
Towards a responsible research climate

Findings from academic researchers in Amsterdam..

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Ilona Kosten
Towards animal free testing:Human skin and gingiva organotypic modelsfor the study of Langerhans Cell biology

Over the last years, it has become generally accepted that animal data is not sufficient for human risk assessment. The drive to reduce, refine and replace the use of test animals (3Rs), particularly in the area of sensitizer risk assessment, (European Commission -Statute-;European Commission -Bill/Resolution-;Williams et al., 2009), has led to increasing pressure to develop superior alternative in vitro human test models. Our studies emphasize that physiologically relevant and immune competent models are needed which not only are human but which also resemble specific three dimensional (3D) tissues, if we are to identify factors in the tissue microenvironment that regulate immune stimulation which in turn will aid the rational development ..

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Willemijn M. Passtoors
Transcriptomic studies in human ageing and longevity

The life expectancy of the general western population has increased dramatically in the last 200 years (1) and is generally expected to continue this rise. Many people reach a high age, but at the same time on average 25% of the lifespan is spent in disability...

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Guus Heynen
Using functional genetics to identify components of cancer relevant signaling pathways

Signaling pathways have pivotal roles in the cell's physiology. They relay information from the cell's outside to the cell's interior and vice versa. This way cells can dynamically react to changing conditions in the extracellular milieu, communicate with other cells and make cell fate decisions like proliferation, cell growth, differentiation, apoptosis and migration...

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Celine Blank
Uterine and Embryo Quality

Features and Models to Predict Successful IVF Treatment..

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Lieke Gijsbers
Vascular Effects of Sodium and Potassium Intake

Elevated blood pressure is a major risk factor for cardiovascular diseases, which is the leading cause of death. Dietary minerals, in particular sodium and potassium, play an important role in blood pressure regulation. While adverse effects of sodium and beneficial effects of potassium on blood pressure have repeatedly been shown in human intervention studies, less is known about other vascular effects of these dietary minerals that could influence cardiovascular disease risk. ­Therefore, we investigated the blood pressure effects of sodium and potassium intake in healthy humans in a broader (patho)physiological context, focusing also on endothelial function, arterial stiffness, fluid regulation and heart rate...

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Anton van de Woestijne
Vascular Risk Of Lipid Genotype And Phenotype In Patients With Arterial Disease

The first research into plasma lipid levels dates back to the 18th century. Albrecht von Haller described aorta plaques in 1755 and noted that a yellow mush effused between the muscular fibre and the intima of the vascular wall. Cholesterol was given its name in 1816, and was subsequently shown to be present in blood and in the atherosclerotic plaques...

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