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Contents



            Chapter 1   General introduction                                   8

            Chapter 2   Differential cooperation of killer cell granzymes in breast   18
                        cancer immunotherapy
                        Manuscript in preparation

            Chapter 3   Extracellular Granzyme K Modulates Angiogenesis by Reg-  34
                        ulating Soluble VEGFR1 Release From Endothelial Cells
                        Front Oncol. 2021 Jun 9;11:681967

            Chapter 4   Pediatric Medulloblastoma Express Immune Checkpoint    53
                        B7-H3
                        Clin Transl Oncol. 2022 Jan 5

            Chapter 5   Immunotherapy in Medulloblastoma: Current State of     62
                        Research, Challenges, and Future Perspectives
                        Cancers (Basel). 2021 Oct 27;13(21):5387.

            Chapter 6   Extracellular granzymes do not interfere with the PD-1/  88
                        PD-L1/2 immune checkpoint axis
                        Manuscript in preparation

            Chapter 7   Summarizing discussion                                 104

            Appendum    English Summary                                        116
                        Dutch samenvatting                                     118
                        Curriculum Vitae                                       120
                        List of publications                                   121
                        Acknowledgements                                       124
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