Page 20 - Rob Holtackers

| Chapter 1
10

acquisition. Chapter 7 describes a rare case of a gargantuan left ventricular
arrhythmogenic pseudoaneurysm with significant thrombus formation. 3D dark-blood
LGE with the dynamic TI mechanism was performed to enable accurate tissue
characterization using high isotropic resolution and optimal dark-blood contrast. In
Chapter 8, the performance of novel dark-blood LGE is evaluated in a cohort of mitral
valve prolapse patients for the detection of papillary muscle scar and compared to
conventional bright-blood LGE. Chapter 9 focuses on the effect of novel dark-blood
LGE on the MIB, a key parameter guiding patient management decisions. The expected
improvement in ischemic scar detection offered by novel dark-blood LGE may impact
MIB estimation compared to conventional bright-blood LGE when these images are
read in conjunction with first pass perfusion images. Another case report follows in
Chapter 10, describing a case with a persistent microvascular obstruction-like lesion
following radiofrequency ventricular tachycardia ablation post-myocardial infarction.
Three months after ablation therapy, novel dark-blood LGE proved crucial to
discriminate the, at that time point highly uncommon, microvascular obstruction-like
lesion from ventricular thrombus formation. Finally, in Chapter 11, an overall
discussion on the development, validation, and clinical relevance of the novel dark-
blood LGE method is presented. Its performance, ease of use, and clinical availability
are compared against other blood-suppressed LGE methods and conventional bright-
blood LGE. Near the end, perspectives for future research are introduced and briefly
discussed.

References

1. Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of
atherosclerosis. Nature 2011;473(7347):317-325
2. Strike PC, Steptoe A. Systematic review of mental stress-induced myocardial ischaemia. Eur
Heart J 2003;24(8):690-703
3. Takaya N, Yuan C, Chu B, et al. Presence of intraplaque hemorrhage stimulates progression
of carotid atherosclerotic plaques: a high-resolution magnetic resonance imaging study.
Circulation 2005;111(21):2768-2775
4. World Health Organization. Global Health Estimates 2020: Deaths by cause, age, sex, by
country and by region, 2000-2019 (2020). Retrieved June 16, 2021, from
https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates
5. Khan MA, Hashim MJ, Mustafa H, et al. Global epidemiology of ischemic heart disease:
Results from the Global Burden of Disease Study. Cureus 2020;12(7):e9349
6. Nowbar AN, Gitto M, Howard JP, et al. Mortality from ischemic heart disease. Circ
Cardiovasc Qual Outcomes 2019;12(6):e005375
7. Moran AE, Forouzanfar MH, Roth GA, et al. Temporal trends in ischemic heart disease
mortality in 21 world regions, 1980 to 2010: the Global Burden of Disease 2010 study.
Circulation 2014;129(14):1483-1492
8. Rijksinstituut voor Volksgezondheid en Milieu (RIVM). Zorguitgaven hart- en vaatziekten
(2019). Retrieved June 16, 2021, from https://www.volksgezondheidenzorg.info/
onderwerp/hart-en-vaatziekten/kosten/zorguitgaven