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| Chapter 1

            acquisition.  Chapter  7  describes  a  rare  case  of  a  gargantuan  left  ventricular
            arrhythmogenic pseudoaneurysm with significant thrombus formation. 3D dark-blood
            LGE  with  the  dynamic  TI  mechanism  was  performed  to  enable  accurate  tissue
            characterization  using  high  isotropic  resolution  and  optimal  dark-blood  contrast.  In
            Chapter 8, the performance of novel dark-blood LGE is evaluated in a cohort of mitral
            valve  prolapse  patients  for  the  detection  of  papillary  muscle  scar  and  compared  to
            conventional bright-blood LGE. Chapter 9 focuses on the effect of novel dark-blood
            LGE on the MIB, a key parameter guiding patient management decisions. The expected
            improvement in ischemic scar detection offered by novel dark-blood LGE may impact
            MIB estimation compared to conventional bright-blood LGE when these images are
            read in conjunction with first pass perfusion images. Another case report follows in
            Chapter 10, describing a case with a persistent microvascular obstruction-like lesion
            following radiofrequency ventricular tachycardia ablation post-myocardial infarction.
            Three  months  after  ablation  therapy,  novel  dark-blood  LGE  proved  crucial  to
            discriminate the, at that time point highly uncommon, microvascular obstruction-like
            lesion  from  ventricular  thrombus  formation.  Finally,  in  Chapter  11,  an  overall
            discussion on the development, validation, and clinical relevance of the novel dark-
            blood LGE method is presented. Its performance, ease of use, and clinical availability
            are compared against other blood-suppressed LGE methods and conventional bright-
            blood LGE. Near the end, perspectives for future research are introduced and briefly


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