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Table of contents




                  Chapter 1    General Introduction                                       7

                  Chapter 2    Chemical Similarity to Identify Potential Substances of Very High   29
                               Concern – an Effective Screening Method

                  Chapter 3    Evaluating Chemical Similarity as a Measure to Identify Potential   51
                               Substances of Very High Concern

                  Chapter 4    ZZS Similarity Tool: the Online Tool for Similarity Screening to   79
                               Identify Chemicals of Potential Concern

                  Chapter 5    Variability in Fish Bioconcentration Factors: Influences of Study   101
                               Design and Consequences for Regulation


                  Chapter 6    Persistence, Bioaccumulation and Toxicity-Assessment of Petroleum   119
                               UVCBs: a Case Study on Alkylated Three-Ring PAHs

                  Chapter 7    General Discussion                                       149


                               References                                               163

                               Summary                                                  179

                               Samenvatting                                             185

                               Curriculum Vitae                                         191

                               List of Publications                                     193


                               Dankwoord                                                197
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