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Table of contents







                 CHAPTER 1  General introduction                                         7

                 CHAPTER 2  The  NKG2A–HLA-E  axis  as  a  novel  checkpoint  in  the  tumor
                            microenvironment                                            17

                 CHAPTER 3  NKG2A is a late immune checkpoint on CD8 T cells and marks repeated
                            stimulation and cell division                               35

                 CHAPTER 4  NKG2A blockade potentiates CD8 T cell immunity induced by cancer
                            vaccines                                                    69

                 CHAPTER 5  Impact  of  the  conserved  MHC  I   molecule  QA-1   on  conventional
                                                                     B
                                                       B
                            cancer therapies                                           109
                 CHAPTER 6  General discussion and future perspective                  131

                 APPENDIX  Nederlandstalige samenvatting                               149

                            List of publications                                       151

                            Curriculum vitae                                           152

                            Dankwoord                                                  153
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