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Table of Contents




               Chapter 1   General introduction                                        7
               Chapter 2   Characterizing disease trajectories in genetic frontotemporal dementia   21
                         2.1   Cognitive profiles discriminate between genetic variants of
                             frontotemporal dementia                                  23
                         2.2  Longitudinal cognitive changes in genetic frontotemporal
                             dementia within the GENFI cohort                         45
                         2.3  Longitudinal brain atrophy rates in patients with presymptomatic
                             genetic frontotemporal dementia                          71

               Chapter 3   New sensitive cognitive instruments in the frontotemporal dementia
                         spectrum                                                    107
                         3.1   Exploring abstract semantic associations in the frontotemporal
                             dementia spectrum in a Dutch population                 109
                         3.2   A cognitive composite for genetic frontotemporal dementia:
                             GENFI-Cog                                               135
                         3.3  Emotion recognition of morphed facial expressions in
                             presymptomatic and symptomatic frontotemporal dementia, and
                             Alzheimer’s dementia                                    163
               Chapter 4   Memory impairment in frontotemporal dementia              185
                         4.1  A meta-analytic review of memory impairment in behavioural
                             variant frontotemporal dementia                         187
                         4.2  Episodic memory impairment in genetic frontotemporal
                             dementia: a GENFI study                                 209
                         4.3  Differences in discriminability and response bias on Rey Auditory
                             Verbal Learning Test delayed recognition in behavioural variant
                             frontotemporal dementia and Alzheimer’s disease         237
               Chapter 5   Mindfulness-Based Stress Reduction in presymptomatic genetic
                         frontotemporal dementia: a pilot study                      257
               Chapter 6   General discussion                                        281

               Chapter 7   English and Dutch summary                                 307
                         English summary                                             308
                         Nederlandse samenvatting                                    310
               Dankwoord                                                             313
               Curriculum vitea                                                      316
               List of publications                                                  317
               Phd portfolio                                                         321
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