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CHAPTER 11     Barriers and facilitators for therapeutic drug monitoring of beta-
                               lactams and ciprofloxacin in the ICU: a nationwide cross-sectional
                               study                                                   197

                CHAPTER 12     The  effect  of  therapeutic  drug  monitoring  of  beta-lactam  and
                               fluoroquinolones on clinical outcome in critically ill patients: the
                               DOLPHIN trial protocol of a multi-centre randomised controlled trial  221

                CHAPTER 13     Cephalosporin-related neurotoxicity in a critically ill child: a call for
                               ceftriaxone therapeutic drug monitoring                 237

                 PART IV       FUTURE DIRECTIONS OF THERAPEUTIC DRUG MONITORING        247

                CHAPTER 14     Therapeutic drug monitoring of antibiotics in critically ill patients:
                               current practice and future perspectives with a focus on clinical
                               outcome                                                 249

                CHAPTER 15     Model-informed  precision  dosing  of  antibiotics  in  pediatric
                               patients: a narrative review                            267

                CHAPTER 16     A review of scavenged sampling for sustainable therapeutic drug
                               monitoring: do more with less                           291

                CHAPTER 17     General discussion and future directions                309

                APPENDICES     Summary                                                 347
                               Nederlandse samenvatting (Dutch summary)                353
                               List of publications                                    358
                               Affiliations of co-authors                              360
                               PhD portfolio                                           363
                               About the author                                        365
                               Dankwoord (Acknowledgements)                            366
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