The behavioural consequences of cerebral small vessel disease
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Cerebral small vessel disease (cSVD) is frequently seen on FLAIR MRI of older adults. White matter hyperintensities (WMH), lacunes of presumed vascular origin (lacunes), microbleeds and (sub)cortical atrophy are the well known ‘traditional cSVD makers’. cSVD is very common in persons aged above 60 years, it’s incidence increases non-linearly with age, and its progression is thought to be related to baseline cSVD load and vascular risk factors. The clinical spectrum and the prognosis of cSVD is highly heterogeneous and ranges from very mild symptoms to full blown stages of dementia and even death. With the aid of conventional MRI it has proven to be very difficult to predict which patients with cSVD are at highest risk to develop these severe clinical symptoms, and who will not. Therefore other factors apart from the ‘traditional cSVD markers’ might determine the transition to incident dementia in some, while leaving others unaffected. Such ‘other factors’ could be the microstructural integrity of the white matter, (cSVD extending beyond lesions visible on conventional MRI) and brain volumes of structures known to be related to behavioural symptoms.
publication | |
ISBN | 978-94-628-4087-4 |
Titel | The behavioural consequences of cerebral small vessel disease |
Auteur(s) | Ingeborg W.M. van Uden |
Taal | English |
Publicatiedatum | 2018 |
Aantal pagina's | 257 |
Bindwijze | eBook |
Imprint | ProefschriftMaken |
Verschijningsvorm | eBook |
eBook url | https://www.globalacademicpress.com/ebooks/inge_van_uden/ |